These data suggest that PCI(20) is safe and effective in patients with NSCLC.

A simulation of a membrane reactor for the water gas shift reaction is carried out by means of a 1D pseudo‐homogeneous nonisothermal mathematical model. The composite membrane consists of a dense layer of Pd (selective to H2) supported over a porous ceramic layer. The effect of temperature, overall heat‐transfer coefficient, and mode of operation on the membrane reactor performance and stability are analyzed, and the results obtained are compared with those corresponding to a reactor with no hydrogen permeation. © 2009 American Institute of Chemical Engineers AIChE J, 2009

Study objectives:To evaluate the relation among several symptoms that occur commonly in cancer patients: trouble sleeping, fatigue/ sleepiness, depressed mood, and pain in a large cohort of cancer patients undergoing treatment in a community oncology practice. Methods: Demographic, clinical, and patient reported outcomes data from 11,445 cancer patients undergoing treatment in a large community oncology practice were analyzed using structural equation modeling. The data were split so that a model was constructed using half of the patients; this model was then cross-validated on the remaining patients. Results: Fatigue was best represented as a latent variable, and significant direct effects were found for trouble sleeping, depressed mood, and pain. Also, there were significant indirect effects of these variables on fatigue. The effect of depressed mood on fatigue and pain was mediated by trouble sleeping, and the effect of trouble sleeping on fatigue was mediated by pain. conclusions: These results predict that interventions aimed at treatment of trouble sleeping, depressed mood, and pain will improve fatigue in patients with cancer. Further, these data predict that treatment of trouble sleeping will improve pain management in this population.