Sore throat is a common complaint in general practice, but doctors do not agree on the best method of treatment. Earlier trials of sulphonamide drugs gave conflicting results (Rhoads and Afremow, 1940;Freis, 1944;Clodfelter, 1945; Commission on Acute Respiratory Disease, 1945), but more recently MacDonald and Watson (1951) and Landsman and her colleagues (1951) both concluded that the sulphonamide treatment they used was not effective. As with many of the earlier trials, the patients treated by MacDonald

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