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2005 Carboxylic amides Q 0490Synthesis and Antiinflammatory Activity of New N-Acyl-5-bromoanthranilamides. -(DOLZHENKO-PODCHEZERTSEVA, A. V.; KORKODINOVA, L. M.; VIZGUNOVA, O. L.; KOTEGOV, V. P.; VASILYUK, M. V.; Khim.-Farm. Zh. 38 (2004) 8, 27-28; Permskaya gos. farm. akad., Perm' 614600, Russia; Russ.) -Mischke 03-097

A series of 17 new substituted amides and hydrazides of N-acyl-5-bromanthranilic acids were synthesized. The antimicrobial activity of these compounds with respect to St. aureus and E. coli was evaluated. It was found that of N-chloracetyl-5-bromanthranlic acid methylamide and hydrazide significantly suppressed the growth of test microbes, with a minimum inhibitory concentration of 15.6 mg/ml against St. aureus and 15.6 -31.5 mg/ml against E. coli. The other tested compounds were significantly less active. 483 0091-150X/07/4109-0483

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