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The objective: to study the incidence of gynecological diseases, clinical and hormonal parameters of the menstrual cycle in patients with benign hyper-plastic processes of breasts. Patients and methods. 65 women with various forms of mastitis were investigated. The following investigations were conducted: mammologistic and gynecological investigation, mommologistic X-ray investigation, ultrasound of breasts and of the pelvic organs, endometrial aspiration biopsy that was followed by cytology; when it was necessary the diagnostic laparoscopy, colposcopy, hysteroscope with curettage and morphological investigation of the endometrium, hormone research and rectal temperature measurements were conducted. Results. The frequency of the benign breast diseases was set: fibrocystic disease of breast – 32 women (49.2±6.20%), fibrous of breast – 16 women (24.6±5.34%), nodular of breasts – 8 women (12.3±4.07%), fibroadenoma – 6 women (9.2±3.59%), nodular disease of breasts on the background of fibroid changes – 3 women (4.6±2.60%). All in all, 96.9±2.14% of the patients had any gynecological diseases. Thus, the average age of the ‘debut’ of mastitis was 31.4±1.09 years; the hyper-plastic processes in the uterus was 35.2±1.17 years. Anovulation was detected in 17 (47.2±8.3%) patients, the lack of the luteal phase (NLF) was detected in 11 (30.6±7.6) patients. Conclusions. Identified hormonal changes are typical for patients with the hyper-plastic processes of the reproductive organs with different localization (breasts, uterus, ovaries). Due to the commonality of the hormone changes in most cases mastitis is combined with the various gynecological diseases (96.9±2.14%). Key words: gynecological pathology, hormonal changes, breast, factors of risk.

Global data show that the probability of occurrence of placenta praevia is increased after treatment with the use of assisted reproductive technology (ART) from 2 to 6 times. However, until now it remains unknown what factors contribute to this increased risk. The objective: perform a retrospective analysis of histories of the births which were complicated by placenta praevia. Determine the frequency of this pathology in the control group where the pregnancy was the result of self-fertilization and the group where the pregnancy was the result of ART. Patients and methods. We have processed statistically the 20 919 birth histories from four Kyiv hospitals (№ 1, 2, 5 and 7) that took place in 2015. ART pregnancy occurred in 391 cases. Results. The retrospective analysis of birth histories found 86 placenta praevia that was 0.38% of the total number of births. 8 cases of placenta praevia that was 2.04% were found among 391 ART pregnancies. Thus placenta praevia in ART group is 5 times greater than in control group of natural pregnancies. Intrauterine pathology was detected in 63% cases of ART pregnancies which was 2.5 times higher than the control group. Conclusions. ART increases the number of pregnant women with placenta praevia in 5 times in comparison with natural pregnancies. Pregravid training with operative treatment in case of the intrauterine pathology reduces the number of pregnancies with the placenta praevia. The obtained data did not allow determining the final mechanism of occurrence of placenta praevia. Key words: аssisted reproductive technology, intrauterine pathology, placenta praevia.

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This article describes the clinical case mix uterine fibroids and pregnancy 11–12 weeks diagnosed with trisomy 21 in the fetus hrosomi. The history of the study of uterine fibroids, current views on the pathogenesis, etiology and treatment. Highlighted describes the practical value that indicates the need for regular preventive medical examinations of women of reproductive age, the importance of planning pregnancy and choice of treatment for fetal malformations and tumors of the uterus. Key words: uterine fibroids, pregnancy, surgery.