In 63 patients with suppurative bone process the activity of N-acetyl-fi-D-glucosaminidaze lysosomal enzyme in urine as well as oxyproline and hexuronic acids excretion were evaluated. Significant changes in metabolism of collagen and proteoglycans of osseous organic matrix were detected and it was confirmed by high excretion of their structural components. The more active and vaster the suppurative process was the more quantitative excretion of collagen and glu- cosaminoglycans and higher enzyme activity were. The suggestion was formulated that high excretion of N-acetyl-fl-D-glucosaminidaze in urine noted in the patients with suppurative inflammatory complications was the indicator of pathologic changes in tubular apparatus of kidney. The detection of excretion of the connective tissue metabolites (oxyproline and hexuronic acids) could be used for the diagnostic and prognostic evaluation of the disease severity and for the choice of method for the treatment of suppurative process.

Total urine excretion of glicosaminoglycanes, glicosaminoglycanes spectnun (electrophoresis on acetate cellulose) activity of 3 lysomal enzymes which participated in the breakdown of glicosaminoglycanes and were very sensitive indicators of renal damage as well as oxyproline (marker of collagene breakdown) and creatinine (typical index of muscle breakdown) were studied in 7 patients with gunshot injuries of lower extremities during the early phase of traumatic disease (on 2, 7, 15 days). Increased urine excretion of glicosaminoglycanes, mainly chondroitin sulfate, N- acetyl--glucosaminidase, oxyproline as well as creatinine was detected. Maximum excretion was noted on day 7 after injury infliction. By day 15 most of biochemical parameters, except for creatinine, returned to normal level. Tire results obtained showed that during early phase of traumatic disease gunshot injury caused the breakdown of the intracellular matrix of connective tissue.