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The aim: To determine the possibility of preventing pathological changes in the gums of rats with indomethacin intoxication using phytogel containing lysozyme and quercetin. The materials and methods: Four phytogels were used: the 1st did not contain lysozyme and quercetin, the 2nd contained lysozyme, the 3rd contained quercetin, and the 4th contained lysozyme and quercetin (Lysozyme-Forte). Experiments were carried out on 5 groups of rats: 1stintact (control), 2ndreceived "empty" gel, 3rdreceived gel with lysozyme, 4thgel with quercetin and 5thgel with lysozyme and quercetin. Gels were applied in the form of applications to the mucous membrane of the gums and cheeks in a dose of 0.5 ml per rat daily for 3 days. Indomethacin was administered in the / gastrointestinal dose of 10 mg/kg once on the 3rd day of the experiment to rats of the 2nd, 3rd, 4th and 5th groups. Euthanasia was carried out on the 4th day of the experiment. In the homogenate of the

Background. To study the effect of lipopolysaccharide on the adsorption of lysozyme on chitin. Methods. Egg white lysozyme, lipopolysaccharide and chitin were used. The lyophilized cells of M. lyzodeikticus were used as a lysozyme substrate. Lysozyme activity was determined by the bacteriolytic method using different concentrations (8-512 μg/ml). Lysozyme adsorption on chitin was determined by the loss of lysozyme from solution after shaking with chitin. The effect of lipopolysaccharide (0.6-40 μg/ml) on lysozyme adsorption was evaluated by the loss of lysozyme from the solution after shaking with 50 mg of chitin. Results. In determining the activity of lysozyme by the bacteriolytic method, the linear nature of the dependence of activity on the concentration of the enzyme is observed only at low concentrations (8-100 μg / ml). Lipopolysaccharide does not affect the bacteriolytic 241 activity of lysozyme, however, dose-dependently increases the adsorption of lysozyme on chitin. Conclusion. Lipopolysaccharide increases the adsorption of lysozyme on chitin.