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Luffolide (4) is a minor metabolite of the sponge Luffariella sp. from Palau. The structure of luffolide was determined by single crystal X-ray analysis. Luffolide is relatively unstable and undergoes a complex cyclization reaction to give the hexacyclic products 5 and 6. Luffolide (4) has some of the anti-inflammatory properties of manoalide (1): this may help to define the chemical reaction between manoalide (1) and phospholipase A2.

Two crystalline modifications of 1-phenylsilatrane are reported. The fl form is orthorhombic, space group Pna2~, with a = 15.855, b = 6"648, c = 11 "635/~. The 7 form is monoclinic, space group P21/n. The structure of the/~ form was determined by direct methods with phases generated from the partially known structure and recycled into the tangent formula. The structure was refined to R=0.076 for 1103 observed reflexions and 0.079 for all 1134 reflexions. The Si-N bond length is 2.156 (4), the Si-C 1-908 (5)