Topicality. The question of the innovative potential of technological entrepreneurship in the region today is extremely relevant, since in modern conditions it is technological entrepreneurship that becomes a decisive factor in the development of the regional economy. However, many of the problems associated with identifying the innovative potential of technological entrepreneurship, as well as the methodology for its evaluation on the meso-level, remain unresolved. Aim and tasks. The purpose of the article is to develop theoretical and methodical provisions and practical recommendations for assessing the level of innovation potential of technological entrepreneurship in the regions of Ukraine. Research results. The article outlines the author's vision of the theoretical and methodological approach to researching the innovative potential of technological entrepreneurship on the meso-level. Author's vision of the essence of the category "innovative potential of technological entrepreneurship in the region" is given on the basis of the system approach, taking into account the structure of interconnections between the elements of the technological entrepreneurship system. The quantitative and qualitative parameters of the development of innovative potential of technological entrepreneurship in the region are proposed to be considered within the framework of two subsystems: innovative personnel potential of technological entrepreneurship (vocational, scientific and research) and economical and ecological (infrastructure, production, investment-financial, market and ecological). It is recommended to quantify the level of innovative potential of technological entrepreneurship in the region on the basis of integrated indicators. The eight-step structure of data integral indexes is given, the algorithm of their calculation and the methodical approach to identifying the level of innovation potential of technological entrepreneurship of the region by means of an estimation scale are given. An information database was formed for calculation of integrated indicators of innovative potential of technological entrepreneurship on the meso-level and the economic burden of each of them was disclosed. The range of users of this methodical approach is indicated. An integrated assessment of the potential of technological entrepreneurship, such as: human potential, economic-ecological and innovative, is carried out according to the regions of Ukraine. In order to improve the level of provision of regions with the innovative potential of technological entrepreneurship, it is proposed to develop an economic mechanism for ensuring the effective use of the innovative potential of technological entrepreneurship at the regional level. Conclusions. The extremely low level of innovation potential of technological entrepreneurship in the regions of Ukraine suggests the need to develop an economic mechanism for ensuring the effective use of the innovative potential of technological entrepreneurship at the regional level.