Background: The identification of nursing students' health profile is essential to develop healthy academic communities. Objective: To analyze students' health profile with a view to designing intervention strategies based on the PRE-CEDE-PROCEED model. Methodology: Quantitative study. Data were collected using the Portuguese version of the following questionnaires: the Fantastic Lifestyle Assessment, the Stunkard Figure Rating Scale, the Rosenberg Self-esteem Scale, and the Psychological General Well-Being Index. A total of 224 undergraduate and postgraduate nursing students participated in this study. Results: Students' overall lifestyle is very good. However, lower scores were found in the Physical activity/Affiliation, changes in Nutrition, altered sleep and low stress management ability, Work/Personality type, and Insight, which suggests that students are less optimistic and positive about life. Conclusion:The intervention plan includes support, education, protection, and prevention should be adapted to students' individual needs and integrated into the curricula.