The tert-amino reaction effect was examined. A new method to synthesize spiro heterocycles is presented. It was shown that the “tert-amino effect” could be applied to the formation of spiro-fused heterocycles. The formation of spiro compounds proceeds in most cases in good yields in a one-pot reaction.

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Triazole derivatives R 0280Reactions of 5-Dialkylamino-1,2,3-thiadiazole-4-carbaldehydes with Amines as a Method for the Synthesis of 1,2,3-Triazole-4-carbothioamides. -A method for the synthesis of the hitherto inaccessible 5-dialkylamino-substituted 1,2,3-thiadiazole--4-carbaldehydes (V) is proposed. Cornfort rearrangement of these compounds induced by primary amines (VI) leads to the targeted 1,2,3-triazole-4-carbothioamide derivatives (VII). -(GLUKHAREVA, T. V.; MORZHERIN*, Y. Y.; DYUDYA, L. V.; MALYSHEVA, K. V.; TKACHEV, A. V.; PADVA, A.; BAKULEV, V. A.; Russ.