Objective. To determine the role of placental growth factor, fibronectin, certain hemostatic parameters and glycodelin in the genesis of early miscarriage.Materials and methods. Venous blood, inpatient medical records (form No.003/u-07), prenatal records (form No.113/u-07) of 94 pregnant women. The software package "Statistica" 10.0 and the programming language "R" version 4.1 were used for statistical analysis.Results. Placental growth factor, fibronectin and glycodelin can be considered as laboratory markers of miscarriage during the first trimester of gestation.Conclusion. The markers of early reproductive losses we have identified underlie the development of endothelial and hemostasiological disorders and morphofunctional inferiority of the endometrium.

Purpose of the study: To evaluate socio-psychological characteristics of women after early reproductive loss and to suggest some forms of psychological support for this category of patients. Material and methods. The sample is represented by 64 women of reproductive age with a primary episode of pregnancy loss. A medical and sociological interview and psychological questionnaire were conducted using the Spielberg-Khanin scale (State-Trait Anxiety Inventory, STAI). Results. The material of the pilot sample demonstrates the significance of the situationally conditioned psychoemotional state (ideas of self-blame and situationally conditioned anxiety) of women with early reproductive loss and shows the directions and forms of possible outpatient psychological intervention after experiencing perinatal loss (respiratory gymnastics, auto-training, neuromuscular relaxation, music and art therapy). Conclusions. In order to maintain mental well-being in women after early reproductive loss, a comprehensive integrative approach is needed, including the provision of medical care by an obstetrician-gynecologist and psychological support by a psychologist at an antenatal clinic.

Objective. To develop a method for determining the risk of reproductive loss in the 1st trimester of pregnancy.Materials and methods. Blood serum, whole blood, medical records of an inpatient (form No. 003/-07), and exchange cards (form No. 113/-07) of 94 pregnant women. Interleukin-6 concentration was assessed in the examined patients by immune-enzyme analysis. The level of leukocytes and monocytes was determined in whole blood by general clinical routine methods on a hematology analyzer. Statistica 10.0 software package and “R” programming language, version 4.1, were used for statistical analysis.Results. The developed logistic regression equation (sensitivity, 87.5%; specificity, 83.33%; classification accuracy, 86.17%) by determining the linear predictor Z makes it possible to assign a pregnant woman to the high risk group for the development of reproductive loss in the 1st trimester (Z > -0.4519).Conclusion. The proposed new method for determining a high risk of developing reproductive loss in the 1st trimester of pregnancy makes it possible to carry out appropriate therapeutic measures to help preserve women’s reproductive health, improve fertility, and increase the birth rate.

The medical and socio-economic significance of the problem of early reproductive losses is determined by a decrease in the birth rate and a deterioration in the demographic situation. Purpose of the study: To evaluate the diagnostic significance of some laboratory parameters characterizing the inflammatory response and their role in early pregnancy losses. Material and methods. Blood serum, medical records, prenatal records of 94 women. The study of interleukin-6 and tumor necrosis factor-alpha was carried out using enzyme immunoassay. The level of white blood cells, banded neutrophils, segmental leukocytes, eosinophils, basophilis, monocytes, lymphocytes and erythrocyte sedimentation rate was determined by general clinical routine methods. Results. Interleukin-6 in combination with segmental leukocytes, monocytes, erythrocyte sedimentation rate can indicate the formation of pro-inflammatory cascade and can trigger abortion mechanisms.