QUESTIONS @ POINT OF CARE markable. One month before admission minimal proteinuria was found. Physical examination did not reveal any significant signs and symptoms beyond edema. Urinalysis demonstrated nephrotic range proteinuria (10 g/day) without any abnormalities of the urinary sediment. Total blood count showed hemoglobin 12.5 g/dL, an erythrocyte sedimentation rate of 40 mm/h, hematocrit 54%. The main biochemical data are summarized in Table I. No monoclonal component was found either in the serum or the urine. Thromboembolic events were not observed. Ultrasonography revealed two normal-sized kidneys and presence of ascites. Chest plain radiography revealed bilateral hydrothorax. Limitation of the oral sodium intake to 2.5 g daily was recommended. The intravascular volume was corrected by intravenous infusions of 20% albumin (2 mL/min for 1-1.5 hours). Intravenous infusions of furosemide (initial bolus-60 mg, followed by continuous infusions-60 mg/h) were

HCV-associated CV can determine the prognosis of chronic HСV infection. AVT is the treatment of choice in all patients with HСV-associated CV. AVT must be combined with rituximab therapy in patients with severe forms of vasculitis.

In this article we discussed the current state of monoclonal gammapathy of renal significance (Monoclonal Gammopathy of Renal Significance MGRS) and revealed problems of B-cell clone secreting nephrotoxic monoclonal immunoglobulin identification. We followed 276 patients with monoclonal gammapathy including patients with non-amyloid nephropathy. The majority of patients had systemic AL-amyloidosis. We established better survival of the treated patients with systemic AL-amyloidosis in comparison with retrospective untreated cohort. We considered current treatment of patients with non-amyloid nephropathy and focused on the crucial role of multidisciplinary approach in management of these patients.

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