Recent studies have indicated that rebamipide is a drug with a pleiotropic effect, covering the upper and lower gastrointestinal tract and also extending beyond it. Rebamipide has prospects for use in endocrinology (in the model of diabetes mellitus, the drug showed hypoglycemic and antioxidant functions, which helped alleviate the symptoms of diabetic nephropathy); an anti-atherosclerotic effect of rebamipide has been shown; in rheumatology, its ability to reduce inflammation in the joints has been revealed; it is used in ophthalmology in dry eye syndrome, lagophthalmos, corneal erosion, etc. (due to its ability to increase corneal and conjunctival mucin-like substances), and can be applied in other areas as well. This article discusses the possibilities of using rebamipide in gastroenterology, depending on the various parts of the gastrointestinal tract.

Purpose: to evaluate the efficacy and safety of the Tummy Ease dietary supplement in the treatment of patients with functional constipation and IBS with a predominance of constipation.