The authors describe a case of erythrokeratodermia variabilis (Mendes da Costa type) in a three-year-old child. They present data on the clinical picture and histological examination. Major stages of the etiology and pathogenesis of the diseases are described.

A case study of the classical form of a rare form of inherited dermatosis, Mibellis disease, featuring unilateral position of the foci in a child aged 3. A histological examination revealed aggregations of parakeratotic cells in epidermis being characteristic of Mibellis disease.

The article describes the current concepts of patient management tactics for patients suffering from atopic dermatitis. It also shows the leading role of the external therapy with the step-by-step administration of moisturizing and softening drugs of the baseline therapy, topical glucocorticoids and calcineurin inhibitors.

Data of the literature concerning peculiarities of the course of ichthyosis hystrix and its pathomorphological picture along the description of a clinical case of the rare form of the disease based on authors' own practice are represented.

The authors summarized the current data on the function of the epidermal barrier, mechanisms of its affection and its role in the development of atopic dermatitis. They present the results confirming the efficacy of complex administration of basic skin care products in the therapy of children suffering from atopic dermatitis. Basic skin care products were cosmetic products from the Emolium series in the form of cream and emulsion as well as skin hygiene products (bath emulsion, cream washing gel).