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Two novel Cd(II) coordination polymers [Cd 4 (C 6 H 4 O 2 N) 8 (H 2 O) 4 ] n (1) and [Cd 2 (C 10 H 2 O 8 )(H 2 O) 6 ] n (2) have been synthesized under hydrothermal condition and structurally characterized. Crystal data: (1), orthorhombic, Pbca, a = 11.4494(19)(2), triclinic, P1, a = 5.5962(7) Å, b = 7.7758(6) Å, c = 9.6975(10) Å, α = 111.981(5) • , β = 101.649(6) • , γ = 98.240(5) • , V = 371.95(7) Å 3 , Z = 2, D calc = 2.603 g·cm −3 . Complex (1) possesses threedimensional infinite structure, while complex (2) adopts two-dimensional layers and the layers are connected by the many types of hydrogen bonds, forming three-dimensional network. Study results of the photophysical properties show that both complexes can emit strong blue fluorescence and complex (1) also emits phosphorescence (λ pl max = 511 nm, τ = 32 ms) in the solid state at room temperature.

Background:An increasing number of studies have described the relationship between velo-cardio-facial syndrome (VCFS) and schizophrenia. in a family-based study, we found that rs10314, a single nucleotide polymorphism (SNP) present in the 3’-flanking region of the CLDN5 gene, was associated with schizophrenia among a Chinese population. High false positive rate is a common problem with the association study of human diseases. It is very important to replicate an initial finding with different samples and experimental designs.Methods:A total of 749 patients with schizophrenia and 383 age and sex matched healthy control subjects in Chinese population were recruited. PCR-based RFLP protocol was applied to genotype rs10314 to see its disease association.Results:The χ2 goodness-of-fit test showed that the genotypic distributions of rs10314 were in Hardy-Weinberg equilibrium in both the patient group (χ2=1.12, P=0.289) and the control group (χ2=0.22, P=0.639). rs10314 was associated with schizophrenia with an odds ratio (OR) of 1.32 in the male subjects (χ2=5.45, P=0.02, 95% CI 1.05-1.67) but not in the female subjects (χ2=0.64, P=0.425, OR=1.14, 95% CI 0.83-1.57). the χ2 test showed a genotypic association only for combined samples (χ2=7.80, df=2, P=0.02). SNP rs10314 is a G to C base change. Frequency of the genotypes containing the C allele was significantly higher in the patient group than in the control group.Conclusions:The present work shows that the CLDN5 gene polymorphism is more likely to be involved in schizophrenic men than women, suggesting that this gene may contribute to the gender differences in schizophrenia.

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