Abstract. Al-Ti-C alloy is a kind of fine refinement agent. However, the wetting of Al/C interface and TiC synthesis are the key technical problems to be solved in the preparation of Al-Ti-C grain refinement. In this paper, the acoustic cavitation effect was used to improve the wettability of Al-Ti/C interface, and improve the thermodynamic conditions of reaction, and thus the Al-Ti-C grain refinement agent was successfully prepared. The wetting properties of Al-Ti/C interface under different conditions were obtained. The results show that the acoustic cavitation effect significantly influences the wetting process. When the sound intensity is greater than the threshold value, the acoustic cavitation effect produces, and then the complete wetting of Al-Ti/C interface can be realized. At the same time, the high temperature effect of the cavitation also prevents the formation of harmful Al4C3 compound, and changes the way of forming TiC compound which is different from the conventional reaction, and enhances the thermodynamics reactivity of the system to promote the TiC synthesis.