INTRODUCTION Tobacco use in any form leads to mortality and morbidity of millions of people every year, not only tobacco users but also non-users by inhaling secondhand tobacco smoke. The objective of this study was to assess predictors of cigarette and shisha use in urban and urban slum communities in Accra, Ghana. METHODS A cross-sectional study design was employed, using a quantitative data collection technique over two months, May to June 2017. Logistic regression was used to study the association between demographic characteristics of respondents and cigarette/shisha use, and data were analyzed in STATA. RESULTSThe study included 389 respondents from urban (135) and urban slum (254) communities in the capital Accra. The prevalence of ever smoking cigarettes, shisha and electronic cigarettes was 24.