Aim To assess knowledge, perception, and practices regarding climate change (CC) among university students and to investigate the relationships between knowledge levels and reported practices in response to CC. Subject and methods A cross-sectional study was conducted among 768 undergraduate students from the practical and theoretical faculties of Al-Azhar University for Girls in Cairo. Results Most (82.6%) students had heard the term CC and believed it affected their communities. Approximately 57.8% of the students possessed good knowledge about the causes and impacts of CC. The utilization of renewable energy sources, reduction of industrial pollution, and proper waste disposal were mentioned by over 90% of the students as measures to cope with CC. The most popular practices among participants were using energy-efficient lightbulbs (89.2%), short distance walking rather than riding (65.4%), and using public transportation rather than private cars (65%). There were significant positive relationships between the students’ knowledge and practice of environmentally friendly actions. In addition, participants’ residence, faculty, and information sources were significantly related to their knowledge. Conclusions Most of the university students were aware of CC and strongly agreed with the general mitigation measures, but they had insufficient knowledge and inadequate practices. CC education focusing on its causes and explaining its relationship with daily activities is highly recommended for youth so that they can adopt climate-friendly practices.