Background: Aloe vera (AV) gels with different concentrations are available in the market. In this study, we evaluate the efficacy of AV gel with two different concentrations in the treatment of oral lichen planus (OLP) compared with placebo. Materials and Methods: A total of 21 females suffering from the clinical signs and symptoms of OLP were grouped into Group (I) patients receiving AV gel divided into two subgroups, subgroup (A) received AV 70% concentration (7 patients) and subgroup)B) received AV 90% concentration (7 patients) and Group (II) control group received placebo (7 patients).Results: There was no statistically significant difference between ulcer sizes at all points of follow-up in Egyptian and Australian AV compared to placebo. The degree of change was higher in Egyptian than Australian AV regarding size, erythema, reticulation, and total area of lesion. However, there was no statistically significant difference between two types of treatment as regards all measured parameters (P > 0.05). Conclusions: AV gel whether Egyptian or Australian is statistically significantly more effective than placebo in inducing marked improvement clinically of OLP. Therefore, AV gel can be considered a safe alternative treatment for patients with OLP. Clinical Significance: AV gel can be considered a safe alternative treatment for patients with OLP.