Nicotine but not cigarette smoke promotes pancreatic DMBA carcinogenesis in mice. Pancreatic adenocarcinomas and PanINs have the same phenotypic appearance as those that occur in humans.
r e v b r a s r e u m a t o l . 2 0 1 5;5 5(1):68-74 REVISTA BRASILEIRA DE REUMATOLOGIA w w w . r e u m a t o l o g i a . c o m . b r Sickle cell disease Systemic lupus erythematosus Hemoglobinopathies a b s t r a c t Objective: To report a case of coexisting systemic lupus erythematosus (SLE) and sickle cell disease (SCD) with a review of the literature on the topic.Methodology: Case report and literature review of the association between SLE and SCD through scientific articles in health sciences databases, such as LILACS, MEDLINE/Pubmed and Scielo, until May 2012. Descriptors used: 1. Sickle cell anemia; 2. Sickle cell disease; 3. Systemic lupus erythematosus; 4. Hemoglobinopathies. Results: The authors describe an association between SLE and SS hemoglobinopathy in an eight-year-old female patient presentingarticular, hematologic and neuropsychiatric manifestations during clinical evolution. Forty-five cases of association between SLE and SCD are described in literature, mostly adults (62.2%), women (78%) and with the SS phenotype in 78% of the cases, and diverse clinical manifestations. Compared with our patient, articular, hematologic and neuropsychiatric manifestations were present in 76%, 36% and 27% of the cases, respectively.Conclusion: SLE and SCD are chronic diseases that have several clinical and laboratory findings in common, meaning difficult diagnosis and difficulty in finding the correct treatment.Although the association between these diseases is not common, it is described in literature, so it is imperative that physicians who treat such diseases be alert to this possibility. Coexistência de lúpus eritematoso sistêmico e doença falciforme: relato de caso e revisão da literaturaPalavras-chave: Anemia falciforme Doença falciforme r e s u m o Objetivo: relatar um caso de coexistência de lúpus eritematoso sistêmico (LES) e doença falciforme (DF) com revisão da literatura sobre o tema. Metodologia: relato de caso e pesquisa da associação entre LES e DF na literatura, através de artigos científicos nas bases de dados de ciências da saúde, como LILACS, MEDLINE/Pubmed r e v b r a s r e u m a t o l . 2 0 1 5;5 5(1):68-74 69 Lúpus eritematoso sistêmico Hemoglobinopatias e Scielo, até maio de 2012.Descritores utilizados: 1. anemia falciforme; 2. doença falciforme; 3. lúpus eritematoso sistêmico; 4. hemoglobinopatias. Resultados: os autores descrevem a associação de LES e hemoglobinopatia SS em paciente do sexo feminino, oito anos, apresentando manifestaç ões articulares, hematológicas e neuropsiquiátricas durante a sua evolução clínica. Na literatura são descritos 45 casos de associação entre LES e DF, sendo a maioria em mulheres (78%) adultas (62,2%), apresentando fenótipo SS em 78% dos casos e com manifestaç ões clínicas variadas. Comparando com a nossa paciente, manifestaç ões articulares, hematológicas e neuropsiquiátricas, estiveram presentes em 76%, 36% e 27% dos casos, respectivamente. Conclusões: LES e DF são doenças crônicas que apresentam diversos achados clínicos e laboratoriais em comum, implica...
-Context -Laparotomy is the gold standard treatment of patients with intestinal obstruction without response to clinical management. Nowadays, literature has been demonstrating the feasibility of videolaparoscopy in the treatment of intestinal obstruction. Objectives -To report the clinical-epidemiological profile of patients with intestinal obstruction submitted to surgery and verify the presence of contraindications for laparoscopy. Methods -It was done a observational, descriptive and retrospective study including adults patients with intestinal obstruction submitted to surgery at Hospital de Clínicas de Porto Alegre, RS, Brazil, between January of 2004 and October of 2008. Results -It was included 135 patients in the study, with a total of 126 patients submitted to open surgery and 9 to laparoscopy. There was similar distribution between gender and the mean age was 59 years (SD ± 16.9). The most frequent site of obstruction was the small bowel and the most frequent etiology was adhesions. Among the patients submitted to laparotomy, 75.4% presented with abdominal distention, 68.3% previous abdominal surgery, 11.9% body mass index >30 kg/m 2 , 4.8% coagulopathy and 3.2% hemodynamic instability. Among the 135 patients, only 5 of them presented with none contraindications for videolaparoscopy. Conclusion -The epidemiological findings of this study are similar to the ones of the worldwide literature. Indications of videolaparoscopy in retrospective analyses have the limitation of subjective evaluation of intestinal obstruction, which was included in this study as a relative contraindication to laparoscopy. HEADINGS -Intestinal obstruction. Video-assisted surgery.
Os idosos são mais propensos a queda do que os jovens e isto os coloca numa situação de extrema vulnerabilidade comprometendo consideravelmente a qualidade de vida dessa clientela. Portanto é importante estudar esse evento, suas causas e consequências para uma melhor utilização e desenvolvimento de medidas de prevenção. O objetivo do estudo foi avaliar a qualidade de vida de idosos atendidos na Atenção Primária a Saúde do Município de Mandaguari cadastrados nas UBS daquele município, que sofreram ao menos uma queda no período de janeiro de 2019 a junho de 2020. A metodologia consistiu em um estudo observacional, transversal, realizado por inquérito telefônico, de abordagem quantitativa. Para levantamento de dados foi utilizado: questionário sociodemográfico para caracterização da população de estudo, Whooqol Bref e Whooqol Old, Índice de Katz, Escala de Lawton-Brody, Escala Geriátrica de Depressão, Escala de Autoestima de Rosenberg e o Índice de Qualidade de Sono de Pittsburgh. Após coleta de dados foi realizado o agrupamento e avaliado cada instrumento com sua pontuação. Observou-se como consequências das quedas: fraturas, demora no tempo de recuperação e alterações na qualidade de vida, como por exemplo na autonomia e qualidade do sono
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