Background: Early onset sepsis is significantly associated with predisposing perinatal risk factors. Various hematological parameters like white blood cell count, absolute neutrophil count, immature to total neutrophil ratio, degenerative changes in neutrophils, platelet count, C -reactive protein and Erythrocyte Sedimentation Rate are good diagnostic tools, which are easily available as rapid screening tests with good sensitivity and negative predictive value. The aim of present study is to evaluate the efficiency of the various blood parameters either alone or in combination in the early diagnosis of the neonatal septicaemia. Methods: The prospective, cross sectional hospital based study conducted over a period of 2 years on 250 newborns. This study was done to find out the predisposing risk factors, utility of sepsis screen to diagnose sepsis that is to evaluate the efficacy of various hematological parameters in diagnosing early onset sepsis. Results: Absolute neutrophil count has 87.5% sensitivity, 83.65% specificity, 51.03% PPV and 79.5% NPV. Platelet count has 93.33% sensitivity, 25% specificity, 25.92% PPV and 93.02% NPV. Creactive protein has 91.45% sensitivity, 85% specificity, 22.05% PPV and 86% NPV. Micro Erythrocyte Sedimentation Rate has 64.44% sensitivity, 51.25% specificity, 20.41% PPV and 76.64% NPV. Conclusion: Various hematological parameters like white blood cell count, absolute neutrophil count, immature to total neutrophil ratio, degenerative changes in neutrophils, platelet count, C-Reactive Protein and Erythrocyte Sedimentation Rate are good diagnostic tools, which are easily available as rapid screening tests with good sensitivity and negative predictive value.

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Background: Obesity is characterized by an abnormally large adipose tissue mass which imposes additional stress to cardio-respiratory system during exercise. The purpose of this study is to evaluate the cardiac response to exercise in normal weight, overweight and obese young adults. Methods: The present work was conducted on total 210 young adults of MMU, Mullana, Ambala, (Haryana) of which 70 forming the normal weight group, 70 forming overweight group and 70 forming obese group in MMU, Mullana, Ambala (Haryana), for assessing the cardiac parameters in response to exercise. Results: The mean PR was increased with increasing BMI but it was not significant (p>0.05). In response to exercise PR was increased very highly significantly (p<0.001) in all the three groups. There was no significant (p>0.05) difference in mean PR found between boys and girls. The mean values of blood pressure i.e. SBP, DBP, MAP and PP were increased with increasing BMI but the increase was not significant (p>0.05) and in response to exercise blood pressure was very highly significantly (p<0.001) increased in all the groups. There was no significant (p>0.05) difference found in blood pressure between boys and girls in all the three groups. Conclusion: The HR and BP was more in overweight and obese subjects as compared to normal weight. In response to exercise, cardiac parameters were increased in all the three groups.