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Osteoporosis is a major cause for morbidity in elderly and is further accentuated by the low levels of estrogen in postmenopausal women. Recognition of bone changes early by estimating the levels of bone turnover markers in the post menopausal women in comparison with pre menopausal women would aidin decreasing the disability caused due to fracture. Aim: To find the difference between the levels of ALP and urinary hydroxyproline in pre menopausal and postmenopausal women. Materials and Methods: In our study 45 post menopausal women and 45 premenopausal women attending the OPD for different reasons were recruited and after obtaining informedconsent, blood sample and urine samples were collected. Alkaline phosphatase (ALP) was estimated inserum sample and Hydroxy proline levels were estimated in the urine sample. Result: Both the serum ALP and urinary hydroxyproline levels were significantly (p<0.001) elevated in postmenopausal women. Conclusion: Bone turnover markers play a role in assessing the bone health in post menopausal women and also aid in prognosis when an individual is on bone formation drugs.

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BACKGROUND & OBJECTIVES The wide reaching negative social impact of non-healing chronic diabetic ulcers is emphasised by the estimate that 70 million of the world population might be affected by diabetes by 2025 and these people will be physically and socially handicapped if they develop foot problems. A vital cog in the wheel of wound healing is Epidermal Growth Factor. Hence a novel approach for combating longstanding diabetic wounds is external application of growth factors. This study has been done with the view to evaluate the efficacy of Epidermal Growth Factor in accelerating the healing of diabetic foot ulcers and also to assess its tolerability. This study compares the Epidermal growth factor Versus the standard therapy of wound with antiseptic solution and moist saline dressing in healing of diabetic ulcer foot. METHODS Sixty cases of diabetic ulcers (Study group-30 and control group-30) were included in this study. Factors tabulated and analysed. RESULTS & OBSERVATIONS The overall rate of healing of ulcers in EGF group is 86.67% and in the control group is 66.67%. CONCLUSION The conclusion of this study is that recombinant Epidermal Growth Factor is effective in the healing of diabetic ulcers at a significantly higher rate.