P. Biginelli reported the synthesis of functionalized 3, 4 dihydropyrimidine-2 (1H)-ones via three component condensation of an aromatic aldehyde, urea and ethylacetoacetate. This multicomponent reaction is of much importance due to excellent pharmacological properties of dihydropyrimidines. In this account, we synthesized some halo substituted indole dihydropyrimidines and evaluated their antimicrobial activity. The minimum inhibitory concentration (MIC) was determined by micro dilution technique in Mueller-Hinton broth. The MICs were recorded after 24 hours of incubation at 37 °C. These results are promising, showing these compounds are biologically active.

The study of binuclear complexes of copper(II) is a very active and highly interesting field due to their significance in bioinorganic chemistry, magneto chemistry, material science, superconductivity and multi electron redox chemistry. Due to the surface-active properties of copper(II) stearate with 2-aminobenzothiazole, the complexes exhibit many applications in agrochemical industries as dispersing agents, foaming and wetting agents. In the present investigation solid complexes of Cu(II) stearate with 2-amino-6-methoxybenzothiazole and 2-amino-6-nitrobenzothiazole have been synthesized and characterized by elemental analysis and their IR, NMR, ESR spectral studies. All the synthesized complexes are coloured and their purity was checked by Thin Layer Chromatography.

Attempts have been made to prepare for the first time the octasubstituted-triphenodioxazines and triphenodithiazines heterocycles by cyclisation of 3,6-dichloro-2,5-bis(2',4',5'-trichloroanilino)-1,4-benzoquinone and condensation. This wasfollowed by cyclisation of substituted 2-aminobenzenethiol respectively with chloranil and bromanil in ethanolic solution of fused sodium acetate in the presence of benzoyl chloride in nitrobenzene. Their structures were confirmed on the basis of their chemical and spectral analyses. Moreover, the biological activity of these compounds was evaluated against the test organisms viz -E.coli, S. aureus, B. subtilis, M.luteus and C. albicans. These compounds synthesized from 2,4,5-trichloroaniline appeared to possess significant antimicrobial activities and an explicit correlation between structure and biological activity was also observed.© Versita Warsaw and Springer-Verlag Berlin Heidelberg.