Nine title compounds were synthesized and investigated in the Born test for their antiplatelet activities against collagen, ADP, adrenaline, and platelet activating factor (PAF) as inducers of the aggregation. Using collagen three compounds with IC50 values below 100 microM were found (3b, 3e, 3i). Activities in nanomolar concentrations were observed against ADP (3b, IC50 = 9.4 nM), adrenaline (3i, IC50 = 5.8 nM), and platelet activating factor (3e, IC50 = 0.45 nM).

New 1H-Pyrazole-4-carboxamides with Antiplatelet Activity. -9 Title compounds of type (I) are prepared and investigated in the Born test for their antiplatelet activities against collagen, ADP, adrenaline, and platelet activating factor as inducers of the aggregation. Derivatives (I) show the best results with activities in nanomolar concentrations. -(REHSE*, K.; KOTTHAUS, J.; KHADEMBASHI, L.; Arch.

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