No abstract

The 1-{[(1H-1,2,3-Triazol-4-yl)methoxy]phenyl}-1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives 5 were synthesized by a simple and efficient method, i.e., by the four-component, one-pot condensation reaction of phthalohydrazide 4, a (propargyloxy)benzaldehyde 1, an active methylene compound 3 (malononitrile or ethyl cyanoacetate), and an azide 2 in the presence of Cu(OAc) 2 /sodium l-ascorbate as catalyst and 1-methyl-1H-imidazolium trifluoroacetate ([Hmim](CF 3 COO)) as an ionicliquid medium in good to excellent yields (Scheme 1).

[(1,2,3-Triazol-4-yl)methoxy-phenyl]-2H-indazolo[2,1-b]phthalazine-trione derivatives were synthesized in a simple and efficient method from the one-pot four-component condensation reaction of phthalhydrazide, aromatic propargyloxy aldehydes, active methylene compounds (dimedone and 1,3-cyclohexanedione), and azides in the presence of Cu(OAc)(2)/sodium ascorbate and p-toluenesulfonic acid as catalysts in good to excellent yields.

ZnO-nanoparticles, as a recyclable heterogeneous catalyst, efficiently promoted the one-pot threecomponent Mannich reaction of ketones, aromatic aldehydes and amines in water to afford the corresponding β-amino carbonyl compounds in good to excellent yields and with moderate diastereoselectivity. The method offers a new modification of the Mannich reaction with a simple workup procedure.

Copies of 1 H NMR and 13 C NMR spectra of compounds.