Coronavirus disease 2019 (COVID-19) is an infectious disease that causes acute respiratory illness. It was first reported in Wuhan, China. The virus has spread rapidly around the world. Epidemiological studies performed in children found that most children infected with COVID-19 were asymptomatic or had mild symptoms. However, about 10% developed severe symptoms, needed oxygen support, and were admitted to critical care units 1 . The most common route of coronavirus transmission to children is via household contact 2 . No specific drugs have been approved to treat COVID-19 infections in children. Many clinical trials of drugs for the treatment of COVID-19 have been conducted. Some drugs were proven their efficacy for adult patients, but none as yet demonstrated satisfactory outcomes for children [3][4][5][6][7][8][9] . Analyses of in vitro data for hydroxychloroquine, an analogue of chloroquine, showed that it effectively inhibited coronavirus replication [10][11][12] . Hydroxychloroquine blocks coronaviral entry by obstructing glycosylation in the host receptor, thereby viral replication is inhibited by increasing endosomal pH. Hydroxychloroquine also has an immunomodulatory effect by decreasing

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