Introduction: Midazolam, a water-soluble benzodiazepine, is non-irritant on intravenous injection and has a shorter duration of action than diazepam. In this research, we evaluated the induction time achieved with midazolam and compared with thiopentone. We also observed the hemodynamic effects following induction with midazolam and thiopentone. In the current study, we also studied undesirable or unwanted effects of the two drugs. Material and methods: The present study was conducted at Civil Hospital, Aizawl Mizoram in thedepartmentof Anaesthesiology and Critical Care. The study was conducted between November 2018 to October 2019. A clinical study was carried out in hundred patients with a physical status of ASA I and ASA II patients, patients between 20-50 years of age and weight 45-70 kg were selected and were divided into two groups each group consisting of fifty patients. Group A-Midazolam (0.2mg/kg) and Group B-Thiopentone (5mg/ kg). A routine preanaesthetic checkup was carried out before the operation. The procedure of anaesthesia to be given was explained to the patients and written informed consent was taken accordingly. Results: The mean age (in years) of the midazolam group was 35.54 ± 8.5 and it was 34.06 ± 10.2 in the thiopentone group. We found a statistically significant difference of weight, spontaneous closure of eye, Loss of lid reflex between both the groups. Patient Good acceptance was good in 16 (66.67%) participants in midazolam and 8 (33.33%) participants in the thiopentone group. Conclusion: We conclude that midazolam is a satisfactory substitute to thiopentone.