Extensive resection of a giant ameloblastoma tumor results in a large defect in both bone and skin tissues that poses a major challenge in their reconstruction. AnOsteocutaneous fibular free flap may be suitable for reconstruction of these complex defects. We describe two cases of reconstruction of complex maxillofacial osteocutaneous defects using an osteocutaneous fibular free flap. Postoperatively, the survived free flaps showed good aesthetic results. Hence, an osteocutaneous fibular free flap may be an appropriate choice to reconstruct large and complex multi-component maxillofacial defects.