Benzofurans display a wide array of pharmaceutical activities. The present work incorporates the synthesis of some novel benzofuran derivatives. The compound 1 (z)-3-amino-7methoxy-N1-(2-oxoindolin-3-yliedene)benzofuran-2-carbohydrazide was synthesized by refluxing carbohydrazide and isatin. The compound 1 formed the key intermediate for the synthesis of compounds 2a-c. The structures of prepared derivatives were established by physical and spectral methods such as elemental analysis, FTIR, 1HNMR and Mass. The molecular docking studies was performed to detect the behavior of compounds towards target proteins. The derivatives were further screened for antibacterial and antifungal analysis.