Background: Breast cancer is the most prevalent cancer and one of the most common mortality causes among females worldwide. Accordingly, it is a main concern of scientists and doctors. Evolving serum tumor markers helping to early diagnosis of the breast cancer and estimating important prognostic factors is then mandatory. Among them are the cancer antigen 15-3 (CA15-3) as well as the carcinoembryonic antigen (CEA). Some researchers concluded their prognostic importance while others not. Aim of the study: This research was aimed at assessing the prognostic function of CA 15-3 and CEA in the Egyptian females. Patients and methods: Research participants are 120 BC patients and 30-year-old and BMI corresponding safety checks; the rates of CEA serum and CA 15-3 were studied and associated with the clinicopathological features of BC patients. Results: Our study showed that both markers increase significantly between healthy controls and patients with BC, and gradually increased with severity of the disease. Conclusion: our findings suggest that the levels of serum CA 15-3 and CEA were closley related to the prognosis of breast cancer, that showing a gradual increase with the severity of the disease, supporting their role as biomarkers of prognosis.

Background: in Egypt, Breast carcinoma is the most common malignancy affecting women. It is claimed for 32 % of cancer in women. It is essential to clarify and assess prognostic factors associated with the breast cancer as they are the corner stone to identify the high risk groups who can benefit from adjuvant therapy and improving their disease prognosis. Aim of the study: in this study, we aimed to assess the value of serum omentin-1 levels as prognostic markers for breast cancer in Egyptian females. Patients and methods: 120 BC patients and 30 age and BMI matching health controls are the subjects of the study; we assessed the omentin-1 levels in the serum and correlated them with the clinicopathologic aspects in the BC patients. Results: our study showed that omentin-1 is significantly differing between healthy controls and BC patients, and revealed gradual increase with disease severity. Conclusion: our findings suggested that omentin-1 could be diagnostic marker for early cases detection and associated with breast cancer prognosis, supporting its role as prognostic biomarkers.