The coordinated development of the territorial spatial pattern and its function is an important prerequisite for the realization of regional high-quality development. This paper aims to reveal the evolutionary characteristics of the spatial–temporal pattern and the coupling coordination level of the “production-living-ecological” spaces (PLES) in Jilin Province from 1998 to 2018 by using the entropy method, a coupling coordination model and spatial analysis methods, and proposes the optimization paths for the four regions of the province. The results indicate that the scale of the ecological space was the largest, mainly concentrated in the eastern region. The production space was mainly concentrated in the central and western regions, and the scale of the living space was the smallest, but increased slightly, mainly concentrated in the central regions. The PLE functions in every county and city are at the coupling coordination levels of mild and moderate imbalance. Eastern Jilin should take the ecological function as the lead, and should improve the production and living functions; Central Jilin should maintain the production and living functions and improve the ecological function; Western Jilin should strengthen ecological restoration and accelerate the transformation and development of the green production function. This study can provide references for the optimization of the provincial territorial space layout in order to improve the regional territorial space coordination and sustainable development.

Inflammation is a common complication of many chronic diseases. It includes inflammation of the parenchyma and vascular systems. Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD)-dependent histone deacetylase, which can directly participate in the suppression of inflammation. It can also regulate the activity of other proteins. Among them, high mobility group box 1 (HMGB1) signaling can be inhibited by deacetylating four lysine residues (55, 88, 90, and 177) in quiescent endothelial cells. HMGB1 is a ubiquitous nuclear protein, once translocated outside the cell, which can interact with various target cell receptors including the receptor for advanced glycation end-products (RAGE), toll-like receptor (TLR) 2, and TLR4 and stimulates the release of pro-inflammatory cyto-/chemokines. And SIRT1 has been reported to inhibit the activity of HMGB1. Both are related to the occurrence and development of inflammation and associated diseases but show an antagonistic relationship in controlling inflammation. Therefore, in this review, we introduce how this signaling axis regulates the emergence of inflammation-related responses and tumor occurrence, providing a new experimental perspective for future inflammation research. In addition, it explores diverse upstream regulators and some natural/synthetic activators of SIRT1 as a possible treatment for inflammatory responses and tumor occurrence which may encourage the development of new anti-inflammatory drugs. Meanwhile, this review also introduces the potential molecular mechanism of the SIRT1-HMGB1 pathway to improve inflammation, suggesting that SIRT1 and HMGB1 proteins may be potential targets for treating inflammation.

Frequent human activities have led to different types of land use conflicts which seriously restricted the multi-functional land use and the optimal allocation of resources. Optimizing the development and utilization pattern of land space, carrying out strategic layout, taking all aspects into consideration, and promoting green production and lifestyle are important measures to alleviate the contradiction between human and land and realize the harmonious coexistence between human beings and nature. Therefore, we constructed an evaluation index system of production-living-ecological (PLE) functions in Jilin Province, and analyzed the characteristics of PLE functions via evaluation models and a spatial concentration index. Obstacle degree model and normalized revealed comparative advantage index (NRCA) were used to identify regional dominant function and diagnose obstacle factors, and function zoning and optimization strategies were carried out. The results showed that the average score of ecological function was higher than production and living functions; the spatial agglomeration degree of the three functions was low and the distribution was scattered; the regional functions were affected and hindered by obstacle factors, including total book stock in public libraries, the proportion of nature reserve area, grassland coverage rate, and the proportion of industrial and mining storage land area. Jilin Province was divided into 14 types of advantage function areas and optimization strategies were put forward. The concept of functional regionalization was applied to measure regional multifunctionality at provincial scale, which enriched the theory and practice of territorial spatial pattern optimization, promoted the coordinated development of territorial space, and provided references for provincial territorial space planning and regional sustainable development.