Purpose: Near infrared spectroscopy (NIRS) is an emerging technology that can measure tissue oxygen saturation levels (StO2) and has many potential clinical applications. NIRS devices have been studied in various disease states in the pediatric as well as adult populations. A review of this technology, with its potential applications and a review of current evidence is presented. Principal findings: NIRS-derived regional tissue oxygen saturation (StO2) is superior to pulse oximetry as it measures tissue oxygen saturation and reflects imbalance between oxygen supply and local demand. Becoming more widely available, it still does not have a firmly established role due to its technical limitations and to the lack of large multi-centric randomized controlled studies necessary to confirm its utility, cost-benefit effectiveness and role in improving patient outcomes. Conclusion: Widespread availability, ease of use, non-invasive nature and continuous data display makes it an attractive option for bedside clinical monitoring.

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