The purpose of the study was to research the change in the psychical status and functional state of the central nervous system of high school leavers taking the Unified State Exam (USE) in the dynamics of the academic year. 85 high school leavers of the 11th form were put under study. The functional state of the CNS was determined by the method of computer chronoreflexometry, psychical status – with the help of “the Methodology for Diagnosing Learning Motivation and Emotional Attitude to Learning in Middle and High School”, “Spielberger's Methodology for Identifying Personal and Situational Anxiety”, and “Determination of susceptibility to stress”. It was found that the boys and girls of the 11th form had the maximum level of motivation for learning at the beginning of the school year. By the end of the school year, the girls' level of motivation for learning decreases while the achievement motivation and anxiety level increase significantly. The level of personal anxiety among girls is also considerably higher than among boys. At the beginning of the school year stress resistance among boys is higher than among girls. Рreparation for the USE during the academic year cause significant changes in the functional state of the CNS, which are more pronounced in schoolgirls. The results of the study can be put into the basis for monitoring the state of psychosomatic health of high school leavers as well as be used as markers when performing psychocorrectional activities to restore an optimum functional CNS state and a psychoemotional status.