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Aim of the study: To evaluate the diagnostic value of crevicular fluid immunoregulatory biomarkers in cases with inflammatory periodontal diseases. The study included a total of 97 patients aged 21 to 55 years with inflammatory periodontal disease (gingivitis — 22 patients; mild periodontitis — 31 patients; moderate periodontitis — 19) as well as 25 persons with healthy periodontium (the control group). A conventionally accepted clinical and instrumental examination revealed that all the patients with inflammatory periodontal diseases featured the most typical signs of periodontal issues: in the crevicular fluid — an increase in the levels of proinflammatory cytokines and chemokines (IL-1β, IL-6, IL-17, TNF-α), a decreased level of anti-inflammatory cytokine IL-1RA, and an increased concentration of vascular endothelial growth factor (VEGF). A ROC analysis showed that the increased content of VEGF, IL-8, IL-1β, IL-6 in the crevicular fluid is of a high diagnostic value in terms of detecting initial inflammation in the gum tissues, whereas the biomarkers pointing at periodontal destructive changes included high levels of VEGF, TNF-α and chemokines.

— High-resolution microfocus computed tomography performed on a Skyscan 1176 (Bruker) device was used to study morphological features of the canal-root systems of the upper jaw first molars in residents of the European part of Russia. An analysis of coronal, axial and sagittal sections of 134 upper jaw first permanent molars removed for medical reasons revealed variations in the canal-root system structure. In 85.8% of the cases, the first upper molars had three separate roots: two vestibular and one palatal; in 14.2% of the cases the roots make up different fusions. The palatal root bent in the buccal direction in 52.9% of the cases, while the mesiobuccal root bent in the distal direction in 87.9% of the cases. The greatest variety of curvatures was observed in the distal-buccal root: towards the mesial side — in 28.3% of the cases, another 21.6% of cases being curved towards the distal side. The palatal root in 90.3% of the cases had one canal; 9.7% of the cases featured two canals, while the distal-buccal root in 73.9% of the cases had one canal, and two canals — in 26.1% of the cases. In 89.6% of the cases, the mesiobuccal root had two canals; in 10.4% of the cases — one canal. The mesiobuccal root of the first upper molars was of an oval shape, elongated in the vestibular-oral direction, the most common structures being those of Type IV (43,3%), II (25.4%), III (8.2%) and VI (7.4%) by F. J. Vertucci. The occurrence rate of extra types of root canal structure was 7.4%.

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Relevance. Tooth splints used to immobilize lower jaw fragments lead to the progression of periodontitis.Purpose. To study changes in periodontal tissues in patients with fractures of the lower jaw during immobilization with dentitional double jaw splints.Materials and methods. Patients with periodontitis during the treatment of fractures of the lower jaw were examined.Results. In patients with periodontitis who have a fracture of the lower jaw, inflammatory and destructive processes in periodontal tissues progress during the immobilization of fragments by the orthopedic method (tooth splints).Conclusion. Comprehensive treatment of periodontitis in fractures of the lower jaw, including dynamic magnetotherapy (DMT) and the treatment of periodontal pockets with liniment of cycloferon, reduces the severity of inflammatory and destructive processes in periodontal tissues.