Absrracf. In spite of an abundant literature on antiandrogen treatment with cyproterone acetate (CA) there have been no objectively measured results to prove statistically the possible superiority of CA over combined oral contraceptive pills in the treatment of acne vulgaris. A multicenter study was therefore done, in which two preparations containing CA in combination with ethinylestradiol (EE) were compared with a marketed combined oral contraceptive pill. The preparations studied were: 1) CA 2 mg + EE 50pg (DianeR), 2) CA 2 mg + EE 35 pg (DianeR mite), 3) Levonorgestrel 150 pg + EE 30 pg (NeovlettaR). A woman was eligible for the 'This study was performed in collaboration with the following gynaecologists and dermatologists:

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Fifteen infertile women with primary amenorrhoea and pronounced oestrogen deficiency were treated with human pituitary gonadotrophin and human chorionic gonadotrophin 71 times ; 61 ovulations (86 per cent) were recorded. Eleven patients conceived (73.5 per cent), three of them twice and one three times, giving 16 pregnancies in all. There were 12 single births and four sets of twins. Two pregnancies ended in abortion. On average one pregnancy resulted from 4.5 treatments and clinical symptoms of overstimulation occurred in 2 cycles (2.8 per cent).IT is important to select patients for treatment with human gonadotrophins carefully in order to choose those who will respond and to avoid complications such as multiple births and ovarian overstimulation (Gemzell and ROOS, 1966;. In general, women with normal but quiescent ovaries who have low or undetectable levels of urinary follicle stimulating hormone (FSH) should be selected for treatment. In this study 15 patients with primary amenorrhoea, infantile genitals and low excretion of urinary FSH were treated for infertility with human pituitary gonadotrophin (HPG) and human chorionic gonadotrophin (HCG). MATERIALS AND METHODS GonadotrophinsHuman pituitary gonadotrophin was prepared from whole frozen pituitaries according to the first step of a procedure developed by Roos for the isolation of pure FSH (Roos and Gemzell, 1964, 1965;Roos, 1968). The yield was about 18 mg. per gland. The FSH activity was 25 to 35 i.u. per mg. (2nd IRP-HMG) and the LH activity was 20 to 30 i.u. of HCG per mg. The ratio between i.u. of FSH and i.u. of LH varied between 0 5 and 2 -0.The human chorionic gonadotrophin (HCG) used was Pregnyl (Organon).HPG and HCG were administered by intramuscular injection. HPG was diluted in 2-3 ml. of saline. Assay MethodsUrinary oestrogen. At first assays were restricted to the estimation of oestrone, oestradiol-17P and oestriol by the method of . During the last two years the rapid method for the estimation of total oestrogens in urine described by Brown et al. (1968) has been used. 58

The cervical mucus was studied with regard to changes in sialic acid content and sperm receptivity. The data were correlated with the urinary total oestrogen excretion in anovulatory women treated with human pituitary gonadotrophins (HPG). With increasing total oestrogen excretion the sialic acid content decreased and the sperm receptivity increased. At a total oestrogen level of about 60 μg/24 h the respective patterns of the curves were reversed and higher values for total oestrogen were actually associated with a decrease in sperm receptivity and an increase in sialic acid content. The possible significance of these observations is discussed.