Summary. Tbiry and double re-entrant j'ejuiia] loops were prepared in adult sheep and young lambs to study antibody responses following local and systemic administration of soluble and particulate antigens. Systemic administration of both living Brttcclta abortus and ferritin elicited an IgG response in serum and intestinal secretion. Repeated local infusions of living and killed Br. abortus into isolated intestinal loops failed to elicit a significant response. However, local infusions of egg albumin or ferritin resulted in ths appearance in intestinal secretion of substantial amounts of antibody most of which was associated with IgA. The results obtained using lambs demonstrated that local antibody production associated with IgA occurred after antigenic stimulation of intestinal loops in animals as young as 3 weeks of age.INTRODUCTION.

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