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Reactions of 2-hydroxy-N -phenylbenzamide with semicarbazide hydrochloride and thiosemicarbazide resulted in the formation of new ketimines, semicarbazone and thiosemicarbazone of 2-hydroxy-N -phenylbenzamide, respectively. The organogermanium(IV) complexes have been synthesized by reacting trimethylgermanium chloride and triphenylgermanium chloride in a 1:1 molar ratio with these ketimines using microwave as well as conventional heating method for comparison purposes. The authenticity of these ligands and their complexes has been established on the basis of elemental analysis, melting point determinations, molecular weight determinations, infrared, 1 H and 13 C nuclear magnetic resonance, ultraviolet, and mass spectral studies. These studies showed that the ketimines coordinated with the germanium atom and, accordingly, the trigonal bipyramidal environment around the metal atom has been established for the complexes. Both the ketimines and their complexes have been screened for their antimicrobial activities against a variety of fungal and bacterial strains and were found positive in this respect. The pesticidal activity of both the ligands and their metal complexes against the Corcyra cephalonica has also been tested.

A series of Bi(III) and As(III) complexes with two N∩S donor ligands, 1-(4-chloro-2-oxo-2H-chromen-3-yl)-methylene)-thiosemicarbazide (L1H) and N′-[1-(2-oxo-2H-chrome-3yl-ethylidene]-hydrazinecarbodithionic acid benzyl ester (L2H) have been synthesized by the reaction of BiCl3 and Ph3As with ligands in 1 : 1 and 1 : 2 molar ratios. All the synthesized compounds were characterized by elemental analyses, melting point determinations, and a combination of electronic, IR, 1H NMR, 13C NMR spectroscopic techniques, and X-ray diffraction for structure elucidation. In order to evaluate the effect of metal ions upon chelation, both the ligands and their complexes have been screened for their antimicrobial activity against the various pathogenic bacterial and fungal strains. The metal complexes have shown to be more antimicrobial against the microbial species as compared to free ligands. Both the ligands and their corresponding metal complexes have been tested for their antifertility activity in male albino rats. The marked reduction in sperm motility and density resulted in infertility. Significant alterations were found in biochemical parameters of reproductive organs in treated animals as compared to control group. It is concluded that all these effects may finally impair the fertility of male rats.

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