Saltwater has invaded the coastal aquifer along the southern Adriatic coast of the Po Plain in Italy. The topography, morphology and land use of the region is complex: rivers, canals, wetlands, lagoons, urban, industrial and agricultural areas and tourist establishments all coexist in a small area. Water table and iso-salinity maps show that in four study areas (Ancona-Bellocchio, Marina Romea, San Vitale Forest, Cervia) out of five, the water tables are below sea level and saltwater has replaced freshwater in the aquifer. The fifth area (Classe Forest) has a relatively pristine freshwater aquifer thanks to an average water-table height of 2m above sea level, a lower hydraulic conductivity (< 7.7m/day) and a continuous dune system along the coast. Only in this area is the topography high enough to maintain freshwater heads that can counteract saltwater intrusion according to the Ghyben-Herzberg principle. Furthermore, the climate, with an average yearly precipitation of 606mm and an average temperature of 14.4°C, allows for little recharge of the aquifer. Ongoing subsidence, encroachment of sea water along rivers and canals, as well as drainage from agricultural land also enhance the salinization process

Mycosis fungoides and Sèzary syndrome are the most studied subtypes common cutaneous T-cell lymphomas. The current treatment objective is to improve the clinical manifestations of the disease in the affected areas, to relieve symptoms and to halt disease progression. Patients with early-stage mycosis fungoides are usually managed with skin-directed therapies, whereas patients with resistant or advanced-stage mycosis fungoides or Sèzary syndrome often require systemic drugs. Over the last decade, new drugs have been developed, increasing the breadth of treatment options for cutaneous T-cell lymphomas patients. Mogamulizumab is a first-in-class defucosylated humanized IgG1 κ monoclonal antibody, which exerts its anti-tumour action by selectively binding to C-C chemokine receptor 4 and increasing antibody-dependent cellular cytotoxicity activity against malignant T-cells. Several clinical trials showed that mogamulizumab is able to effectively control the cutaneous T-cell lymphomas in each site (skin, blood, lymph nodes and viscera), improving patients’ symptoms, function and overall quality of life with a manageable safety profile. In this report, we discuss 12 cases of patients with mycosis fungoides or Sèzary syndrome successfully treated with mogamulizumab in real-life clinical practice in Italy.

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En la primera posguerra y tras la creación de la OIT, organismo internacional especializado para el desarrollo de una legislación del trabajo, la vinculación de las instituciones argentinas con el ámbito internacional cobró nuevo impulso, en cuyo desarrollo tuvo un rol preponderante el Departamento Nacional del Trabajo (DNT). Tal vinculación y sus antecedentes constituyeron parte de una dimensión transnacional de la política laboral argentina poco estudiada por la historiografía, la cual forma parte importante de la historia misma de la construcción de tal política. En ese vínculo internacional fue vital la actividad del funcionario departamental Alejandro Unsaín, de lo cual también da cuenta el presente trabajo.

Laura Caruso, El gran barco: el sindicalismo revolucionario argentino a través de la obra de Julio Arraga, Izquierdas, 30, Octubre 2016:1-25 1 El gran barco: el sindicalismo revolucionario argentino a través de la obra de Julio ArragaThe big boat: argentine´s revolutionary sindicalism through the works of Julio Arraga Laura Caruso * …quizá para ustedes la organización política es un gran barco y la organización económica una barquita remolcada por éste. Para nosotros, el gran barco es la organización sindical; es necesario subordinar la acción política a la acción sindical León Jouhaux ** Resumen: El sindicalismo revolucionario, siendo una corriente política muy desarrollada en el mundo obrero urbano de Argentina y Brasil en las primeras décadas del siglo XX, ha sido objeto de escasos estudios hasta hace pocos años. Mucha menos atención recibió uno de sus impulsores cardinales, quien tuvo un rol clave en la instalación y despliegue de dicha corriente en el Rio de la Plata: Julio Arraga. Este trabajo indaga su producción, vida y obra, construyendo una biografía política a partir de sus escritos.Abstract: In spite of the importance of revolutionary sindicalism in the urban working-class world in Argentina and Brasil during the first decades of the 20th century, there are few studies focusing on this subject. Not surprisingly, one of his cardinal figures, Julio Arraga, has received even less attention. This article aims at exploring the production, life and work of Arraga, who had a