QST of PPTs demonstrated good ability to differentiate between people with OA and healthy controls. Lower PPTs in people with OA in affected sites may suggest peripheral, and in remote sites central, sensitisation. PPT measurement merits further evaluation as a tool for phenotyping OA pain.

HighlightsNeural maladaptation in chronic pain conditions is poorly understood.Large scale coordinate based meta-analysis of 266 cutaneous pain fMRI was performed.Results support a shared neural pain response in chronic pain and healthy subjects.Hyperalgesia leads to increased activation in an unchanged neural pattern.Chronic pain patients show functional reorganisation depending on stimulation site.

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