Since the early 1960s the Pummerer reaction has evolved to become an indispensable tool for synthesis, and continues to serve as a source of inspiration for organic chemists. In recent years, many exciting advances have demonstrated the broad scope and synthetic utility of Pummerer methodology and the versatility of thionium ion intermediates.

Seit den frühen 1960er Jahren hat sich die Pummerer‐Reaktion zu einem unentbehrlichen Syntheseverfahren in der organischen Chemie entwickelt. Viele interessante Fortschritte in den vergangenen Jahren unterstreichen die breite Anwendbarkeit und den Nutzen dieser Methode sowie die Vielseitigkeit von Thioniumionen als Intermediate.

No abstract

Synthesis of the ABH Rings of Ecteinascidin 597 Using a ConnectivePummerer-Type Cyclization. -A connective Pummerer-type cyclization involving a N-protected glyoxamide (I) and a cysteine derivative (II) is applied to an asymmetric synthesis of the protected ABH rings of ecteinascidin 597. Subsequent ester hydrolysis and macrocyclization affords the ABH ring system (V) of the natural product. -(SMITH, L. H. S.; NGUYEN, T. T.; SNEDDON, H. F.; PROCTER*, D. J.; Chem. Commun. (Cambridge) 47 (2011) 38, 10821-10823, http://dx.doi.org/10.1039/c1cc13992d ; Sch. Chem., Univ. Manchester, Manchester M13 9PL, UK; Eng.) -M. Paetzel 07-198

Sch. Chem., Univ. Manchester, Manchester M13 9PL, UK; Eng.) -Lindner 47-253