Data and materials availabilityCoordinates and structure-factor amplitudes of the PAL crystal structure that support the findings of this study have been deposited in the Protein Data Bank with the accession code 6HMJ (http://www.rcsb.org/structure/6hmj).

Clickmers are chemical modified aptamers representing an innovative reagent class for developing binders for biomolecules with great impact on therapeutic and diagnostic applications. To establish a novel layer for screening...

Highlights Fully automated RNA aptamer selection. Fully automated selection of 2′deoxy-2′fluoro RNA aptamers. Significant time saving approach.