This study determined if a SystemCHANGE™ intervention was more efficacious than attention control in increasing immunosuppressive medication adherence and improving outcomes in adult kidney transplant recipients during a 6-month intervention phase and subsequent 6-month (no intervention) maintenance phase. The SystemCHANGE™ intervention taught patients to use person-level quality improvement strategies to link adherence to established daily routines, environmental cues, and supportive people. Eighty-nine patients (average age 51.8 years, 58% male, 61% African American) completed the 6-month intervention phase. Using an intent-to-treat analysis, at 6 months, medication adherence for SystemCHANGE™ (median 0.91, IQR 0.76-0.96) and attention control (median 0.67, IQR 0.52-0.72) patients differed markedly (difference in medians 0.24, 95% CI 0.13-0.30, P < .001). At the conclusion of the subsequent 6-month maintenance phase, the gap between medication adherence for SystemCHANGE™ (median 0.77, IQR 0.56-0.94) and attention control (median 0.60, IQR 0.44-0.73) patients remained large (difference in medians 0.17, 95% CI 0.06-0.33, P = .004). SystemCHANGE™ patients evidenced lower mean creatinine and BUN at 12 months and more infections at 6 and 12 months. This first fully powered RCT testing SystemCHANGE™ to improve and maintain medication adherence in
In the United States, nearly 500,000 men who have sex with men (MSM) are at risk of contracting HIV. Men who have sex with men constitute 70% of all new cases of HIV in the United States; within this population, the incidence of HIV infection is the highest among Black MSM. Our integrated review synthesized published behavioral interventions designed to enhance the uptake of and adherence to pre-exposure prophylaxis (PrEP) for the prevention of HIV in the Black MSM population. A search of 4 electronic databases revealed only 7 studies whose samples included Black MSM. Adherence to PrEP medication declined overtime across all studies. No statistically significant changes in safer sexual behaviors were reported. Few studies described theory-driven interventions. Effective interventions are needed to enhance the uptake of PrEP and to reinforce behaviors that prevent HIV transmission among Black MSM.
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