BACKGROUND-It is unclear whether therapy for human immunodeficiency virus type 1 (HIV-1) should be initiated with a four-drug or two sequential three-drug regimens.
Genetic variants predict plasma exposure to efavirenz and nelfinavir, and they may predict virologic failure and/or emergence of drug-resistant virus. These associations with treatment responses must be validated in other studies.
Thomas Campbell and colleagues report findings of a randomized trial conducted in
multiple countries regarding the efficacy of antiretroviral regimens with
simplified dosing.
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