Durian or Durio zibethinus is a tropical fruit originating from Southeast Asia. Durian is often known as "King of Fruits". In Asian countries, durian is widely used as traditional medicine such as antipyretic drugs, anti-malaria, treating skin diseases, jaundice, anti-inflammation, boosting the immune system, wound healing and so forth. In fact, several studies have proven the health benefits of durian fruit such as antimicrobial, ant diabetic, ant cholesterol, antioxidant, antiproliferative, antibacterial, antifungal, and others. The objective of this paper is to describe the effect of durian on cardiovascularespecially blood pressurewhich is still controversial. This paper use literature study involving 18 libraries both national and international journals or books. In conclusion, there are still many people who believe that consumption of durian causes hypertension or high blood pressure, whereas based on research, consumption of durian in a small amount does not affect blood pressure, only for patients with hypertension must be careful in consuming durian in large amounts.   Keywords: durian, blood pressure, systolic, diastolic, heart rate

Dengue Hemorrhagic Fever (DHF) is an endemic disease in various tropical countries that is transmitted through the bite of  Aedes aegypti. One of the prevention of DHF transmission is by using repellent. Repellents that are usually used in the community have high side effects. So we need to find a replacement made from natural components. Flavonoid is one of the compounds in robusta coffee leaves that has a repellent effect. This study used analytical research with a pure experimental research design namely the Posttest Only Control Group Design in the form of a Complete Randomized Design (CRD) conducted from November 2019 to January 2020, consisting of five treatments (negative control, concentration of 10%, 25%, 50% and positive control) and repeated five times. Data were analyzed with One Way Anova, Post Hoc Bonferroni and Probit analysis. The results of study of robusta coffee leaf extract as repellent at a concentration of 10%, 25% and 50% gave protection power to 41.21%, 68.69% and 81.46% with ED50 concentration was 16.834% and ED99 contained at a concentration of 49.788%. The conclusion is the higher the concentration of robusta coffee leaves extract, the higher its protective power as repellent against Aedes aegypti.Keywords:Aedes aegypti, Robusta Coffee Leaves, Repellent AbstrakDemam Berdarah Dengue (DBD) merupakan penyakit endemis diberbagai negara beriklim tropis yang ditularkan melalui gigitan nyamuk Aedes aegypti. Salah satu pencegahan penularan penyakit DBD adalah dengan menggunakan repelan. Repelan yang digunakan di masyarakat umumnya memiliki efek samping yang tinggi sehingga upaya pencarian repelan berbahan alami lebih diutamakan. Flavonoid merupakan salah satu senyawa yang terdapat di dalam daun kopi robusta memiliki efek sebagai repelan. Penelitian ini menggunakan jenis penelitian analitik dengan desain penelitian eksperimental murni yaitu Posttest Only Control Group Design yang berupa Rancangan Acak Lengkap (RAL) dilakukan dari bulan November hingga Januari 2020, terdiri dari lima perlakuan (kontrol negatif, konsentrasi 10%, 25%, 50% dan kontrol positif) dan diulang sebanyak lima kali. Data yang didapatkan dianalisis dengan menggunakan One Way Anova, Post Hoc Bonferroni dan analisis Probit. Hasil penelitian didapatkan bahwa ekstrak daun kopi robusta sebagai repelan pada konsentrasi 10%, 25% dan 50% memberikan daya proteksi sebesar 41,21%, 68,69% dan 81,46% dengan ED50 adalah konsentrasi 16,834% dan ED99 terdapat pada konsentrasi 49,788%. Kesimpulannya semakin tinggi konsentrasi ekstrak daun kopi robusta semakin tinggi daya proteksi sebagai repelan terhadap Aedes aegypti. Kata kunci: Aedes aegypti, Daun Kopi Robusta, Repelan.

Coronary heart disease (CHD) is the number one cause of death globally, caused by accumulation of plaque, a mixture of fat, cholesterol, and calcium deposits in the arteries for years which over time causes narrowing and hardening of the coronary arteries so that oxygen supply in the blood decreases. CHD can  bepotentiallyprevented  with  active  substancescontained  by  plants  such  as  breadfruit.Breadfruit leaf(Artocarpus altilis) is one of the natural ingredients that contain flavonoids, which can reduce cholesterol, triglycerides and LDL in the blood so the risk of CHD will decrease.Objectiveto  describe  the  potential  anticholesterol effects  of  breadfruit in coronary heart diseasecaused  by high cholesterol. This  paper  used  literature  study  involving  16  libraries  both  nationaland  international  books  and  journal.Conclusions:  Breadfruit leaf has the effect of preventing the risk of coronary heart disease by lowering cholesterol, triglyceride and LDL levels in the blood without side effects.  Keywords: breadfruit leaf, flavonoid, coronary heart disease

According to WHO, in 2017 there are an estimated 425 million sufferers of diabetes mellitus. Indonesia is placed in the seventh rank in the world in 2015, with an estimated 10 million sufferers. To reduce the prevalence of type 2 diabetes mellitus, improvements need to be made, such as lifestyle modification and treatment. Most anti-diabetic drugs have high side effects. Corn silk is one of the natural ingredients that contain flavonoids, which can reduce blood fat levels. The dose of corn silk of 500 mg/kg BW is the best substance against diabetic rats from excessive weight loss. Therefore, corn silk can be calculated to have an anti-diabetic effect by using lipids, eliminating free radicals, and increasing antioxidant capacity.