Parenteral alimentation solutions free of cysteine, probably an essential amino acid for premature infants, were administered continuously to eight healthy men through catheters in the superior vena cava and through nasogastric tubes. When the preparation was administered parenterally, the plasma cystine concentration dropped markedly. When feeding was switched to the oral route, the concentration rose immediately, but returned to baseline only when a cystine-containing diet was fed. These studies indicate that the synthesis of cysteine from methionine is limited, even in the adult subject, when cystine-free diets are administered parenterally.

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Twenty-four mongrel dogs were subjected to one of the following operations: sham (biopsy) operation, two-thirds gastric bypass, two-thirds gastric resection and antrectomy with vagotomy.After three weeks all the dogs were given histamine in beeswax injections for a month.Chronic ulcer developed in 50% of dogs with sham operation and 33% of those with antrectomy-vagotomy.None of the dogs with gastric bypass or resec tion developed chronic ulcer. The frequency of superficial ulcer was least in gastric bypass dogs and largest in antrectomy-vagotomy ones.