Lambda cyhalothrin (LCT), a broad-spectrum type II (α-cyano) synthetic pyrethroid pesticide, is widely employed in various agricultural and animal husbandry practices for the control of pests. Acute and chronic exposure to LCT can elicit several adverse effects including oxidative stress. With the objective to investigate nephrotoxicity and neurotoxicity of LCT in mice, we evaluated oxidative stress parameters and histological changes in the kidney and brain of LCT exposed mice. Swiss albino mice were divided randomly into four groups ( n = 6 per group) as: (A) corn oil/vehicle control; (B) 0.5 mg/kg body weight (b.w.) LCT; (C) 1 mg/kg b.w. LCT; (D) 2 mg/kg b.w. LCT. Mice were treated orally for 28 days. LCT exposure significantly increased serum urea nitrogen, creatinine and urea levels. LCT exposure also increased lipid peroxidation, superoxide anion generation, nitrite level and decreased the level of reduced glutathione. The activities of superoxide dismutase, catalase and glutathione- S-transferase were depleted significantly in both kidney and brain. Histological examination revealed marked histopathological changes in the kidney and brain of mice that were more pronounced at high dose of LCT. Thus, results of the present study indicate that 28 days oral exposure of LCT causes oxidative damage to the kidney and brain of mice which in turn could be responsible for nephrotoxicity and neurotoxicity. Nevertheless, further detailed studies are required to prove these effects especially after long-term exposure.

The objective of this study was to predict gestational age of Osmanabadi goats by realtime ultrasonography using measurements of Crown Rump Length (CRL). CRL was measured in 15 Osmanabadi goats, by transabdominal ultrasonography carried out on days 35, 42, 49, 56, 63 and 70 of gestation, those became pregnant after oestrus detection and natural mating following oestrus synchronization in 30 does using double PGF2α injections 11 days apart. Gestational age was calculated by using gestational equations derived from the linear regression analysis. Results clearly demonstrated that biometric parameter CRL was significantly (P ios less than 0.01) correlated with gestational age (r= 0.988) and was a reliable index to predict gestational age in Osmanabadi goats.

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Not available.Key words: Ecodevelopment; National DevelopmentTribhuvan University Journal Volume, XVI, 1993Page: 78-86Uploaded date: 4 October, 2010