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Shrimp culture has become an important industry which is accounting for approximately 18% of the total world's aquaculture economy. Asian and Latin America are major production areas whose economic value is estimated at USD 28 billion per year [1]. However, this highvalue industry has faced serious disease outbreaks, particularly caused by Vibrio bacteria, which have caused widespread losses to farmers. A certain Vibrio species can cause high mortality to shrimp such as V. parahaemolyticus, V. alginolyticus, V. harveyi, V. mimicus, or V. vulnificus. Vibrio bacteria are the major agent responsible for acute hepatopancreatic necrosis disease, shell disease, white gut disease, luminescent disease, red disease, and loose shell [2,3].Antibiotics were widely applied in aquaculture to control pathogenic bacterial infections including Vibrio species. The overuse of antibiotics

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