Heterostemma cucphuongense (Apocynaceae, Asclepiadoideae), a new species from Vietnam is described, illustrated and compared with the similar species Heterostemma succosum Kerr. Heterostemma cucphuongense differs from H. succosum by the morphology of the rachis of the inflorescence, the margins of the corolla lobes and the colour of the adaxial surface of the corolla.
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