No abstract

Bufotenine (1, 5-hydroxy-N,N-dimethyltryptamine) was isolated from seeds of Anadenanthera spp., a tree widespread in the Brazilian cerrado, using an efficient acid-base shakeout protocol. The conversion of bufotenine into N,N-dimethyltryptamine (4) and 5-methoxy-N,N-dimethyltryptamine (5) was accomplished through an innovative and short approach featuring the use of novel bufotenine-aminoborane complex (7). Furthermore, an easy methodology for conversion of bufotenine into 5-hydroxy-N,N,N-trimethyltryptamine (6) was well-established. This is the first study that highlights bufotenine as a resource for the production of N,N-dimethyltryptamines for either pharmacological and toxicological investigations or for synthetic purposes.

O uso de novas tecnologias na transformação de insumos químicos tem importância estratégica para a política de desenvolvimento nacional. O uso de processos competitivos na produção de fármacos, fito e domissanitários, fragrâncias e flavorizantes tem impacto direto no fortalecimento dos nossos setores de química de base e química fina. Neste contexto, os microreatores se apresentam como uma tecnologia atraente por possibilitar um fino controle dos eventos de troca térmica, permitir a intensificação das condições de reação, dispensar espaço físico comumente necessário para a operação de plantas químicas tradicionais, tudo isso em um regime de produção contínua com menor geração de resíduos. Palavras-chave: microreatores, síntese química, processos químicos.New process technologies to transform chemicals have strategic importance to the national development policy. The implementation of competitive processes to produce API, crop protection products, fragrances and flavors has a direct impact to increase the competitiveness of the Brazilian Bulk and Fine Chemical Industries. In this context, the microreactors emerge as a compelling technology. It allows a fine control of heat exchange events and the intensification of the reaction conditions, dispense the industrial area commonly required for the operation of traditional chemical plants, all in a continuous production system with less waste generation.