The main drivers for application of small‐scale reactors in the pharmaceutical industry are the possibility of rapid synthesis and screening of novel drugs as well as the readiness of the scale‐up. The characterization of fluid flow pattern was performed through step‐up and step‐down residence time distribution experiments using a tracer at six different flow rates. Four single‐parameter models were considered for representing deviations from ideal plug flow and ideal laminar flow in tubes. The model that provided the best results was the axial dispersion model and the Peclet and Reynolds numbers could be well correlated. Obtained Peclet values from 44 to 244 were close to Pe > 100, in which axial dispersion can be neglected and the reactor can be considered as plug flow reactor.

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RESUMO-Neste trabalho são apresentados os resultados de rendimento, em batelada, dos produtos intermediários 4-cloro-6-(4-metoxifenoxi)pirimidina, 2-((6-(4-metoxifenoxi)pirimidil-4-il)(metil)amino)etan-1-ol e 6-(4-metoxifenoxi)-Nmetil-N-(2-(4-vinilfenoxi)etil)pirimidin-4-amina, além da confirmação de identidade do produto intermediário (Z)-5-(4-(2-((6-(4-metoxifenoxi)pirimidin-4il)metil)amino)etoxi)benzilideno)tiazolidina-2,4-diona, da síntese da Lobeglitazona (Duvie®), um fármaco que possui atividade farmacológica de combate à diabetes mellitus tipo 2. Os resultados obtidos mostram que foi feita a otimização do processo em termos de rendimento e tempo de reação em relação aos publicados na literatura.